HIV DNA vaccine coordination and trial support
Administrative Core
This program creates DNA-based HIV vaccine candidates and protein boosters to move into a future clinical trial for people at risk of HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11249585 on NIH RePORTER |
What this research studies
The team is developing two DNA plasmid vaccine candidates and adjuvanted Env protein boosters, then testing them in animals to select the best options. They will support GMP manufacturing and prepare regulatory (IND) materials so the HVTN can start a human trial in year five. An Administrative Core coordinates project management, sample distribution, compliance, meetings, and communication with NIH and an external scientific advisory board. Annual reviews and ongoing oversight will guide the program toward clinical testing if the candidates perform well.
Who could benefit from this research
Good fit: Ideal candidates would be people who are HIV-negative and eligible to join an HVTN preventive vaccine trial, as determined by site screening.
Not a fit: People living with HIV are unlikely to receive direct benefit from this preventative vaccine program.
Why it matters
Potential benefit: If successful, this work could lead to a new HIV vaccine candidate entering human trials that might prevent infection in people at risk.
How similar studies have performed: Related DNA and protein-based HIV vaccine efforts have shown immune responses in animals and some early human trials, but a fully protective HIV vaccine has not yet been achieved.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Weiner, David B. — Wistar Institute
- Study coordinator: Weiner, David B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.