HIV care options tailored to patients' needs

Differentiated HIV Care Models: An Implementation Science Study

NIH-funded research Duke University · NIH-11474700

This project compares different ways of delivering HIV care to help adults on treatment or using PrEP stay on treatment, keep the virus suppressed, or avoid infection.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-11474700 on NIH RePORTER

What this research studies

You would be followed at clinics in South Africa where some offer 'differentiated' care (for example, community pick-up, integrated primary care, or stigma-reduction practices) while others use standard clinic services. Researchers will watch clinic processes, interview staff, and do repeated in-depth interviews with clients to learn about what helps or gets in the way. They will also follow groups of clients over time and use medical records and viral load/PrEP data to compare outcomes between the different clinic approaches. The team will look at both health outcomes and the costs and acceptability of adding primary care or stigma-reduction into HIV services.

Who could benefit from this research

Good fit: Adults receiving HIV treatment (ART) or taking PrEP at participating clinics in South Africa would be the ideal candidates for this work.

Not a fit: Children, people not attending the participating clinics, or those outside the study areas in South Africa are unlikely to be included or benefit directly from this project.

Why it matters

Potential benefit: If successful, this work could make it easier for people to stay on HIV treatment or PrEP and increase viral suppression and prevention in real-world clinics.

How similar studies have performed: Other demonstration projects of differentiated service delivery have shown promise for improving retention and convenience, but rigorous multi-site comparisons of clinical outcomes and costs remain limited.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.