HIV, biological aging, and cancer outcomes
HIV Genomic Aging Project in Oncology (HIV-GAP)
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-11160801
This project looks at whether signs of faster biological aging in people with HIV help explain their higher cancer relapse and death rates.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11160801 on ClinicalTrials.gov |
What this research studies
You would be asked to give a blood sample and allow researchers to use your cancer treatment records so they can compare genomic aging markers in people with and without HIV. The team will measure DNA methylation 'epigenetic clocks' and look for age-related clonal hematopoiesis mutations in blood cells to estimate biological age. Those genomic age measures will be linked to clinical outcomes such as cancer relapse and survival after therapy. The work uses samples and data from patients treated at the cancer center to see if accelerated biological aging relates to worse cancer outcomes in people with HIV.
Who could benefit from this research
Good fit: Adults with cancer who are living with HIV—and comparable cancer patients without HIV who are willing to provide blood samples and access to their medical records—are the ideal participants.
Not a fit: People without cancer, children, or patients who cannot or will not provide blood samples or medical records are unlikely to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, this could identify biological markers that help predict which people with HIV are at higher risk of cancer relapse or death and point to closer monitoring or new treatment strategies.
How similar studies have performed: Previous work has shown accelerated epigenetic aging and increased clonal hematopoiesis in people with HIV, but applying these genomic aging markers specifically to explain cancer relapse and survival is a newer approach.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COGHILL, ANNA — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: COGHILL, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: AIDS associated cancer, AIDS related cancer, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus