HIV and cocaine impact blood cell development and heart health
HIV and Cocaine Drive Bone-Marrow Blood (BMB) Barrier Dysfunction and Altered Hematopoietic Stem Cell (HSC) Differentiation Leading to Cardiovascular Disease
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-11111898
This study is looking at how HIV and cocaine use might affect the bone marrow and the way blood cells are made, to help us understand why people with HIV are at a higher risk for heart problems, even if they are on treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11111898 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV and cocaine use affect the bone marrow-blood barrier and the differentiation of hematopoietic stem cells, which are crucial for producing immune cells. The study aims to understand the mechanisms behind the increased risk of cardiovascular disease in people living with HIV, even those on anti-retroviral therapy. By examining the bone marrow environment, the researchers hope to uncover how these factors contribute to heart health issues in this population. The findings could lead to new insights into managing cardiovascular risks associated with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those who also use cocaine or have a history of substance use.
Not a fit: Patients who are not living with HIV or do not have any history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in people living with HIV.
How similar studies have performed: Other research has shown that understanding the interactions between HIV and the immune system can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDREWS, ALLISON MICHELLE — UNIVERSITY OF FLORIDA
- Study coordinator: ANDREWS, ALLISON MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.