HIV and cervical cancer prevention for women in Uganda
Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Uganda (CASCADE UGANDA)
['FUNDING_OTHER'] · MAKERERE UNIVERSITY WALTER REED PROJECT · NIH-11099736
This project offers easier HPV screening and same-day treatments to help women living with HIV in Uganda prevent cervical cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAKERERE UNIVERSITY WALTER REED PROJECT (nih funded) |
| Locations | 1 site (KAMPALA, UGANDA) |
| Trial ID | NIH-11099736 on ClinicalTrials.gov |
What this research studies
As a woman living with HIV, you could be offered simpler HPV screening like self-collected samples or point-of-care HPV testing, visual exams with acetic acid (VIA), and new molecular biomarker tests. If precancer is found, you may be offered same-day cryotherapy, ablation, or excisional treatments delivered at local clinics. The trials are run by Makerere University Walter Reed Project as part of the CASCADE clinical trials network to see which approaches work best in real-world Ugandan clinics. The aim is to identify affordable, scalable methods so more women can be screened and treated quickly.
Who could benefit from this research
Good fit: Ideal candidates are women living with HIV in Uganda, generally aged 25–49, who are eligible for cervical cancer screening.
Not a fit: Women who are not living with HIV, those outside the target age range, or those unable to attend participating clinics may not be eligible or receive direct benefit.
Why it matters
Potential benefit: If successful, the project could expand access to effective, same-day screening and treatment and reduce cervical cancer among women with HIV.
How similar studies have performed: Similar screen-and-treat programs using HPV testing and cryotherapy have reduced precancerous lesions in other settings, though some newer self-sampling and biomarker approaches need more testing in low-resource settings.
Where this research is happening
KAMPALA, UGANDA
- MAKERERE UNIVERSITY WALTER REED PROJECT — KAMPALA, UGANDA (ACTIVE)
Researchers
- Principal investigator: MWESIGWA, BETTY — MAKERERE UNIVERSITY WALTER REED PROJECT
- Study coordinator: MWESIGWA, BETTY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus