HIV-1 Reservoir Monitoring Test to Guide HIV Treatment Decisions
Official title: Clinical Assay to Accurately Profile and Monitor the HIV-1 Reservoir in Chronic-treated Individuals to Guide Treatment Decisions
Funded at Jan Biotech, INC. · NIH-11255801 · Data updated 2026-11-12
A new HIV RNA detection test helps doctors measure hidden virus in people on long-term HIV treatment to better tailor their care.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jan Biotech, INC. NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | August 1, 2026 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $300,000 |
| NIH project number | 1R44AI195231-01 |
| Project ID | NIH-11255801 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV who are on chronic ART and have residual HIV reservoir detectable by the new assay.
✕Less likely to help
Patients not on ART or without reservoir activity detectable by this method may see little or no direct benefit.
What this research studies
This grant supports developing and testing a nonezymatic, direct HIV RNA detection method that works in people who are on antiretroviral therapy and still harbor latent virus. The goal is to provide a quick, sensitive, and quantitative readout of cell-based HIV RNA to inform treatment choices. The work focuses on making the test reliable in diverse patient groups, including those with acute/early infection who are treated, where other methods may fail. If successful, clinicians could use this tool to refine therapy decisions and monitor reservoir dynamics over time.
Why it matters
Potential benefit: If successful, patients could receive more precise treatment decisions and closer monitoring of their HIV reservoir.
How similar studies have gone: Previous reservoir assays have shown mixed performance; this project aims to deliver improved sensitivity and applicability across patient subgroups.
Where this research is happening
-
Jan Biotech, INC.
Ithaca, United States Active
Researchers
- Principal investigator: Huie, Janet L — Jan Biotech, INC.
- Study coordinator: Huie, Janet L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.