Histone helpers and cell fate: how chromatin proteins influence cell growth and reprogramming
Official title: Investigating the Regulatory Roles of Histone Chaperones in Cellular Plasticity
Funded at University of California Riverside · NIH-11371433 · Data updated 2026-11-12
A patient-facing overview of how histone chaperone proteins help control chromatin structure to support healthy cell growth and, when needed, how they influence turning one cell type into another.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM151004-04 |
| Project ID | NIH-11371433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation in this grant; the research is basic biology using cellular models to inform future human therapies.
✕Less likely to help
Immediate patient participation is not part of this grant's activities.
What this research studies
This project explores how histone chaperones manage chromatin to keep cells healthy and proliferating, and how they restrain or enable changes in cell identity. Researchers study factors like CAF-1 that help assemble chromatin during replication and influence which genes are turned on or off. By understanding these processes, scientists hope to learn how cells maintain proper development and how reprogramming can be controlled when needed. The work uses laboratory models to connect basic chromatin biology with the potential to guide future therapies that could affect cell fate in diseases.
Why it matters
Potential benefit: Better understanding of how chromatin proteins control cell growth and identity could lead to new strategies for improving tissue regeneration and treating diseases where cell fate goes awry.
How similar studies have gone: Prior work has shown histone chaperones influence cell fate and reprogramming, supporting the relevance of this line of inquiry.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Cheloufi, Sihem — University of California Riverside
- Study coordinator: Cheloufi, Sihem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.