High urinary phosphate levels may worsen kidney disease by causing inflammation and cyst growth.
Official title: High Urinary Phosphate Induces TLR4-mediated Inflammation and Cystogenesis in Polycystic Kidney Disease
Funded at Michigan Technological University · NIH-10730615 · Data updated 2026-11-12
This study is looking at how too much phosphate in urine might make autosomal dominant polycystic kidney disease (ADPKD) worse, and it aims to find out if certain dietary changes or treatments could help manage the condition better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan Technological University NIH-funded |
| Lab location | 1 site (Houghton, United States) |
| Project start | July 15, 2023 |
| Project end | July 14, 2026 |
| Funding year | 2023 |
| Award (this year) | $469,500 |
| NIH project number | 1R15DK137195-01 |
| Project ID | NIH-10730615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD) who may be affected by dietary phosphate intake.
✕Less likely to help
Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates how high levels of urinary phosphate contribute to the progression of autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that leads to kidney cyst formation and dysfunction. The study will explore the role of toll-like receptor 4 (TLR4) in mediating inflammation and cyst growth triggered by elevated phosphate levels. By examining the effects of dietary phosphate on kidney health and the potential therapeutic role of resolvins, the research aims to identify new strategies for managing ADPKD.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations and treatments that slow the progression of kidney disease in affected patients.
How similar studies have gone: Previous studies have shown that dietary phosphate restriction can slow disease progression in animal models of ADPKD, suggesting that this approach may be promising.
Where this research is happening
-
Michigan Technological University
Houghton, United States Active
Researchers
- Principal investigator: Zhang, Yan — Michigan Technological University
- Study coordinator: Zhang, Yan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.