High shear stress affects gene regulation in lung blood vessel disease
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
This study is looking at how high blood flow and pressure in the lungs affect gene activity in people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to help treat this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10764213 on NIH RePORTER |
What this research studies
This research investigates how high shear stress influences gene regulation in pulmonary arterial hypertension (PAH), a serious condition that can lead to heart failure. By examining the effects of this stress on endothelial and smooth muscle cells in the lungs, the researchers aim to uncover mechanisms that could potentially reverse the disease. The study employs advanced techniques like ATAC Seq and HiChIP to analyze gene expression and chromatin accessibility, providing insights into how these cells respond to changes in blood flow and pressure. Patients with PAH may benefit from the findings, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of pulmonary hypertension not related to high shear stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that reverse the progression of pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Rabinovitch, Marlene — Stanford University
- Study coordinator: Rabinovitch, Marlene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.