High salt diets affect kidney metabolism and blood pressure.
Official title: High Salt Remodels Renal Cortical and Proximal Tubular Metabolism: Metabolic Fuels, Oxidative Stress, and Hypertension
Funded at Medical College of Wisconsin · NIH-11046266 · Data updated 2026-11-12
This study is looking at how eating too much salt affects the kidneys and can lead to high blood pressure, especially for people who are sensitive to salt, to help find better ways to manage these health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2021 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $668,563 |
| NIH project number | 2R01HL151587-05 |
| Project ID | NIH-11046266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with salt-sensitive hypertension, particularly those from African American and Asian populations.
✕Less likely to help
Patients who do not have hypertension or those who are not salt-sensitive may not benefit from this research.
What this research studies
This research investigates how high salt intake impacts kidney metabolism and contributes to hypertension, particularly in salt-sensitive individuals. The study focuses on understanding the metabolic changes in the kidneys when exposed to excessive salt, examining how these changes may lead to increased blood pressure and chronic kidney disease. By using animal models, the researchers will analyze the metabolic pathways involved in energy production and sodium reabsorption, aiming to uncover protective mechanisms that may be impaired in certain populations. The findings could provide insights into dietary recommendations and treatments for hypertension and kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary guidelines and treatments for individuals at risk of hypertension and chronic kidney disease.
How similar studies have gone: Previous research has shown that dietary modifications can significantly impact cardiovascular health, suggesting potential success for this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Cowley, Allen W — Medical College of Wisconsin
- Study coordinator: Cowley, Allen W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.