High-risk stomach pre-cancer: molecular changes in precancerous tissue
Project 1 - Molecular and Cellular Determinants of High Risk Gastric Precancerous Lesions
['FUNDING_P01'] · STANFORD UNIVERSITY · NIH-11179408
This project looks for molecular signs in precancerous stomach tissue to help people with gastric intestinal metaplasia understand which lesions may be more likely to progress toward cancer.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11179408 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will analyze tissue from precancerous stomach lesions using advanced gene-reading tools. They will compare samples across a range of lesion types and use Helicobacter pylori infection status to help sort risk. The team will apply bulk RNA sequencing and spatial transcriptomics to find gene-expression patterns tied to high-risk lesions. Single-cell multi-omics will be used to identify the exact epithelial cells with mutations, copy-number changes, or epigenetic marks associated with cancer.
Who could benefit from this research
Good fit: Ideal candidates are people undergoing endoscopy who have gastric intestinal metaplasia or other precancerous stomach lesions, especially if Helicobacter pylori status is known or can be tested.
Not a fit: People without precancerous stomach changes or with already-advanced gastric cancer may not benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help doctors identify which precancerous stomach lesions are most likely to become cancer, guiding closer monitoring or earlier treatment.
How similar studies have performed: Previous studies, including the PI's earlier work, have identified distinct gene-expression patterns in early gastric cancer, but using spatial and single-cell multi-omic methods on precancerous lesions is a newer approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JI, HANLEE P — STANFORD UNIVERSITY
- Study coordinator: JI, HANLEE P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Detection