High-resolution screening for receptors that many medicines target
A Novel high resolution MS platform for high-throughput screening of G protein-coupled receptors
['FUNDING_R01'] · BATTELLE PACIFIC NORTHWEST LABORATORIES · NIH-11324211
This project is creating a faster, more accurate mass spectrometry tool to detect chemical tags on receptors involved in inflammatory diseases, helping researchers develop better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BATTELLE PACIFIC NORTHWEST LABORATORIES (nih funded) |
| Locations | 1 site (RICHLAND, UNITED STATES) |
| Trial ID | NIH-11324211 on ClinicalTrials.gov |
What this research studies
Researchers are combining ultrahigh-resolution ion mobility separation with very accurate mass spectrometry (a SLIM-Orbitrap platform) to pinpoint where receptors called GPCRs gain phosphate tags. They will focus on CXCR3, a receptor linked to inflammatory conditions, and work to separate and identify complex, multi-phosphorylated peptide forms that current methods often miss. The team will use laboratory samples and advanced instruments to improve sensitivity and speed for site-specific phosphorylation mapping. This work aims to make it easier for scientists to see how drugs and ligands change receptor signaling.
Who could benefit from this research
Good fit: People with inflammatory conditions linked to CXCR3 who are willing to donate blood or tissue samples for laboratory analysis would be most relevant to this work.
Not a fit: Patients without conditions involving CXCR3 or those unable/unwilling to provide samples are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this could help researchers and clinicians better understand drug effects on receptor signaling and support development of more precise anti-inflammatory therapies.
How similar studies have performed: Mass spectrometry has been used to map protein phosphorylation before, but applying SLIM ion mobility with Orbitrap MS for high-confidence, high-throughput characterization of complex multi-phosphorylated GPCR sites is a novel and less-tested approach.
Where this research is happening
RICHLAND, UNITED STATES
- BATTELLE PACIFIC NORTHWEST LABORATORIES — RICHLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACOBS, JON — BATTELLE PACIFIC NORTHWEST LABORATORIES
- Study coordinator: JACOBS, JON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.