High-resolution protein mapping of brain tissue with advanced fluorescence imaging
Spatial proteomics using highly parallel fluorescence hyperspectral and lifetime imaging
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11195545
This project is creating a faster way to map many different proteins at once in brain tissue to help researchers understand Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11195545 on ClinicalTrials.gov |
What this research studies
I would be part of work to develop a new imaging method called Phasor S-FLIM that reads both color and fluorescent lifetime at the same time. That method lets researchers label many proteins in a single staining step and image thick brain tissue with subcellular detail. The team will adapt this approach to profile many Alzheimer-related proteins across large tissue samples. The goal is to make spatial protein mapping faster, less expensive, and practical for many patient-derived samples.
Who could benefit from this research
Good fit: Ideal candidates would include people with Alzheimer's disease or families willing to donate brain tissue or participate in tissue-based research.
Not a fit: People without Alzheimer's, those unwilling to donate tissue, or those seeking immediate treatment would be unlikely to benefit directly from this technology development.
Why it matters
Potential benefit: If successful, this could reveal detailed protein patterns in Alzheimer's brains that point to new diagnostic markers or treatment targets.
How similar studies have performed: Similar fluorescence and spatial-proteomics approaches exist, but this parallel spectral-and-lifetime detection is a novel, more scalable technique with limited prior clinical use.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KESSENBROCK, KAI — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: KESSENBROCK, KAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease