High-resolution MRI to guide Parkinson's deep brain stimulation
UMN Udall Imaging Core
Using advanced MRI to map brain circuits in people with Parkinson's so doctors can better target deep brain stimulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11162397 on NIH RePORTER |
What this research studies
You would get ultra-high-resolution MRI scans at the University of Minnesota's Center for Magnetic Resonance Research. The team uses several MRI techniques (detailed structural T1/T2 and susceptibility-weighted images, diffusion scans for tractography, and resting-state and task fMRI) to map your individual brain anatomy and connections. They build patient-specific anatomical models to plan DBS electrode placement and to pinpoint electrode contacts after surgery. These images support projects developing circuit-based DBS therapies aimed at Parkinson's symptoms.
Who could benefit from this research
Good fit: People with Parkinson's disease who are being considered for or have had deep brain stimulation and who can safely undergo 7T MRI scans are ideal candidates.
Not a fit: People without Parkinson's, those who are not DBS candidates, or people who cannot safely have a 7T MRI (for example due to incompatible implants or severe claustrophobia) are unlikely to benefit.
Why it matters
Potential benefit: Could help personalize DBS targeting to each person's brain circuits, potentially improving symptom control and reducing side effects.
How similar studies have performed: Previous work using imaging-guided DBS and tractography has shown promising improvements in targeting, but patient-specific circuit-based methods are still developing.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Harel, Noam — University of Minnesota
- Study coordinator: Harel, Noam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.