High-resolution maps of non-coding RNAs that control genes
High Resolution Structure Determination of Non-Coding RNAs to Reveal Functional Mechanisms
Researchers are making very detailed 3D maps of small RNAs to see how their shapes control gene activity, which could help people with cancers tied to RNA-driven changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11329722 on NIH RePORTER |
What this research studies
This team uses an advanced cryo-EM scaffolding method to produce atomic-detail images of protein-free non-coding RNAs. They combine these high-resolution structures with lab biochemistry and cell and organism experiments to link RNA shape to function. The project targets both bacterial RNAs that affect biofilms and human untranslated regions (UTRs) that influence gene expression. Findings aim to reveal how specific nucleotides and structures drive biological effects.
Who could benefit from this research
Good fit: People with cancers or tumors suspected to involve abnormal RNA regulation, or patients willing to provide tissue/samples for molecular studies, would be most relevant.
Not a fit: Patients with conditions unrelated to gene regulation by non-coding RNAs or who need immediate clinical treatment are unlikely to benefit directly from this lab-focused work.
Why it matters
Potential benefit: If successful, the work could identify new RNA-based biomarkers or targets that lead to better cancer tests or therapies.
How similar studies have performed: High-resolution protein-free RNA structures are rare but the team’s pilot work using scaffolds has already produced atomic-level RNA maps, making this approach promising but still relatively new.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Toor, Navtej Singh — University of California, San Diego
- Study coordinator: Toor, Navtej Singh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.