High-resolution light-based brain monitor to measure cerebral blood flow after brain bleeding
Coherence engineering of a human brain interferometer to quantitatively and specifically measure cerebral blood flow
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11247158
A new near-infrared, interferometric brain monitor will be used to measure blood flow in people who have had bleeding around the brain (subarachnoid hemorrhage) so delayed brain injury can be spotted earlier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11247158 on ClinicalTrials.gov |
What this research studies
This project develops a bedside optical device that uses interferometric diffuse optics to record blood flow in the brain with many more channels and better signal quality than current methods. The device combines parallel detection and time-of-flight measurements to reduce contamination from scalp tissue and to provide more quantitative cerebral blood flow readings. The team plans to adapt the system for human-head measurements and compare its signals to existing optical approaches and clinical monitoring during the acute period after aneurysmal subarachnoid hemorrhage. The overall goal is a more specific, sensitive bedside monitor that can detect early reductions in brain blood flow linked to delayed cerebral ischemia.
Who could benefit from this research
Good fit: Ideal participants would be adults hospitalized after an aneurysmal subarachnoid hemorrhage who are monitored in acute care settings and at risk for delayed cerebral ischemia.
Not a fit: People without recent brain hemorrhage, those with conditions that block near-infrared monitoring (deep non-superficial lesions), or stable long-term survivors are unlikely to benefit directly from this device study.
Why it matters
Potential benefit: If successful, this could allow faster detection of reduced brain blood flow after subarachnoid hemorrhage, enabling earlier treatment and potentially lowering disability and death.
How similar studies have performed: Previous work using diffuse correlation spectroscopy (DCS) has shown promise for optical cerebral blood flow monitoring but was limited to forehead sampling and relative measures; this interferometric approach is a novel and more advanced extension.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SRINIVASAN, VIVEK JAY — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: SRINIVASAN, VIVEK JAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.