High-resolution imaging of HIV-1 and its interactions
Cryo EM/ET Core
This study is looking at the structure of the HIV virus and how it interacts with our cells using special imaging techniques, with the goal of finding better treatments for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11078367 on NIH RePORTER |
What this research studies
This research focuses on using advanced imaging techniques, specifically cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET), to study the structure of HIV-1 and its interactions with host cells. By examining these viral components in their natural cellular environment, the research aims to uncover critical details about HIV-1 replication and how it interacts with small molecule inhibitors. The project will also develop new technologies to enhance imaging capabilities, particularly in a controlled biosafety environment. This work is expected to provide valuable insights that could lead to improved treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may benefit from new therapeutic strategies targeting the virus.
Not a fit: Patients who are not infected with HIV or those who are not seeking treatment for HIV-related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding HIV-1 replication, potentially resulting in more effective treatments for patients living with HIV.
How similar studies have performed: Previous research using cryo-EM and cryo-ET has shown promise in structural biology, indicating that this approach could yield significant insights into HIV-1.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Zhang, Peijun — University of Pittsburgh at Pittsburgh
- Study coordinator: Zhang, Peijun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.