High-resolution imaging and AI tools to map brain support cells across whole organs
Imaging and computational platform for integrated analysis of biodata
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-11192306
This project will create fast imaging and computer tools to map glial (support) cells across entire brains to help researchers working on conditions like Alexander disease, multiple sclerosis, and Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-11192306 on ClinicalTrials.gov |
What this research studies
The team is building a platform that combines whole‑organ high-resolution imaging with automated computational analysis to create complete, subcellular maps of brain tissue. They will use mouse models to track how glial cells are produced and change over time in development and after injury. Large datasets will be stored, annotated, and analyzed with AI and advanced software to find patterns that are hard to see by eye. The goal is to make it possible to study gliogenesis across space and time in an unbiased, reproducible way.
Who could benefit from this research
Good fit: This project does not enroll people directly, but it is most relevant to adults affected by Alexander disease, multiple sclerosis, or Alzheimer's disease.
Not a fit: People with conditions unrelated to brain glial biology or those expecting immediate clinical treatments are unlikely to receive direct benefit from this lab-based work.
Why it matters
Potential benefit: If successful, this could give researchers new ways to control glial cells and point toward regenerative treatments for neurodegenerative and injury-related brain diseases.
How similar studies have performed: High-resolution imaging and AI analyses have helped answer questions in mouse brain research before, but this integrated whole-organ, subcellular platform is relatively new.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENBAUM, ALON — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: GREENBAUM, ALON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Alexander Disease, Alexander syndrome