High-resolution cell and tissue mapping for leukemia
Core C: High Dimensional Cellular and Spatial Analysis
['FUNDING_P01'] · FRED HUTCHINSON CANCER CENTER · NIH-11177717
This effort uses advanced single-cell and tissue-imaging tools to map leukemia and immune cells in patient samples to help researchers find new targets and markers.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11177717 on ClinicalTrials.gov |
What this research studies
From a patient's view, this core runs cutting-edge lab methods that read individual cells' RNA and proteins and map where they sit inside bone marrow or tissue samples. It uses techniques like single-cell sequencing, CITE-seq (protein + RNA), paired T-cell receptor sequencing, and high-dimensional spatial imaging including multiplex immunohistochemistry and spatial transcriptomics. The core integrates these complex datasets with biostatistics support to reveal new cell types, interactions, and patterns in acute myeloid leukemia. Those discoveries are shared with the research projects supported by the center to guide future biomarker and therapy development.
Who could benefit from this research
Good fit: Ideal candidates are people with acute myeloid leukemia willing to donate blood or bone marrow samples for research.
Not a fit: Patients without AML or those not providing samples should not expect direct benefit from this core's activities.
Why it matters
Potential benefit: If successful, this work could reveal new leukemia cell subtypes and interactions that lead to better diagnostics and more targeted treatments.
How similar studies have performed: Related single-cell and spatial mapping studies have already uncovered treatment-resistant cell populations and new biomarkers in blood cancers, and this core expands those methods for broader discovery.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEWELL, EVAN — FRED HUTCHINSON CANCER CENTER
- Study coordinator: NEWELL, EVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.