High-resolution brain MRI and spectroscopy to spot metabolic signs of Alzheimer's risk
Official title: ADVANCED COMPREHENSIVE MAGNETIC RESONANCE SOLUTION FOR THE NONINVASIVE CHARACTERIZATION OF HIGH RESOLUTION METABOLIC BIOMARKERS OF RISK IN PATIENTS WITH ALZHEIMER'S DISEASE AND DEMENTIA
Funded at Advanced Imaging Research, INC. · NIH-11177037 · Data updated 2026-11-12
This project is building a high-resolution MRI and magnetic resonance spectroscopy system to find early metabolic signs of Alzheimer's and related dementias in patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Imaging Research, INC. NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,275,000 |
| NIH project number | 5R44AG085817-03 |
| Project ID | NIH-11177037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be older adults with mild cognitive impairment, early Alzheimer's disease, other AD-related dementias, or people considered at risk and willing to undergo MRI/MRS scans.
✕Less likely to help
People without cognitive concerns, those with MRI contraindications (for example certain implanted devices or severe claustrophobia), or patients who cannot travel to participating sites may not benefit from this project.
What this research studies
They are developing ADRD360, a combined hardware-and-software package to collect clearer structural MRI and metabolic MRS data from the human brain. The team will build advanced radio-frequency coils and improved shimming and processing to push imaging and spectroscopy to much higher resolution than standard clinical scanners. The improved images and spectra aim to localize metabolic signatures that could indicate early risk for Alzheimer's and related dementias. If successful, these noninvasive scans could help doctors detect disease-related changes earlier than current methods.
Why it matters
Potential benefit: Could enable earlier and more precise detection of brain changes linked to Alzheimer's risk, potentially guiding monitoring or earlier interventions.
How similar studies have gone: Structural MRI and MRS have previously detected metabolic changes in Alzheimer's, but combining the very high-resolution hardware and software proposed here is a newer, less-tested approach.
Where this research is happening
-
Advanced Imaging Research, INC.
Cleveland, United States Active
Researchers
- Principal investigator: Srinivasan, Ravi — Advanced Imaging Research, INC.
- Study coordinator: Srinivasan, Ravi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.