High-resolution 3D protein mapping for brain tissue
A 3D super-resolved platform for rapid and highly multiplexed proteomics
This project develops a fast, high-resolution method to map many proteins at once in brain tissue to help researchers better understand Alzheimer's and related brain conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Panluminate INC. NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11190941 on NIH RePORTER |
What this research studies
From a patient's perspective, this project is building a new lab technique called pan-OptiX S3D that combines tissue expansion and rapid protein labeling so tissues can be imaged in 3D at subcellular detail. The team will first test and validate the method in rodent brain tissue to map neural circuits and disease features like amyloid plaques. The approach aims to let researchers label unlimited protein markers without damaging samples and image whole tissue sections in multiple colors. If it works, this tool could reveal disease-related changes that are hard to see with current methods.
Who could benefit from this research
Good fit: People with Alzheimer's disease or families interested in donating brain tissue for research or taking part in future studies that use advanced tissue imaging would be the most relevant participants over time.
Not a fit: This is a lab-based methods development project validated in animal tissue, so patients seeking immediate treatment or clinical care are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, researchers could produce detailed 3D protein maps of Alzheimer’s-affected brain tissue that help identify disease mechanisms and new targets for diagnosis or therapy.
How similar studies have performed: Related techniques like tissue expansion microscopy and single-molecule localization methods have shown success, but combining pan-SSExM with FLASH-PAINT for unlimited 3D multiplexing is a novel approach.
Where this research is happening
New Haven, United States
- Panluminate INC. — New Haven, United States (Active)
Researchers
- Principal investigator: M'saad, Ons — Panluminate INC.
- Study coordinator: M'saad, Ons
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.