High-resolution 3D MRI mapping to better find and describe prostate cancer
3D High Resolution Magnetic Resonance Fingerprinting for Prostate Cancer
['FUNDING_R37'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11127690
This uses a fast, high-resolution 3D MRI method to better find and describe prostate cancer in men being evaluated because of elevated PSA or other concerns.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11127690 on ClinicalTrials.gov |
What this research studies
If you join, you'll get a fast, high-resolution 3D MRI scan that maps tissue properties across your prostate using a technique called magnetic resonance fingerprinting (MRF). The team will create detailed T1 and T2 maps and synthesize contrast-weighted images from those maps instead of relying on conventional MRI pictures. The scans are designed to be consistent across scanners and repeated visits, aiming for submillimeter resolution in under five minutes. The approach is meant to help doctors spot clinically important cancers more reliably and reduce unnecessary or blind biopsies.
Who could benefit from this research
Good fit: Men being evaluated for possible prostate cancer—for example after an elevated PSA, abnormal digital rectal exam, or those scheduled for prostate MRI or biopsy—would be ideal candidates.
Not a fit: Men who cannot have MRI because of implanted medical devices or severe claustrophobia, or those already diagnosed and receiving treatment, are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this could make MRI scans more consistent and accurate, helping doctors find significant prostate cancers sooner and potentially avoid some unnecessary biopsies.
How similar studies have performed: Prior pilot studies of quantitative MRI techniques, including early MRF work, have shown promise for improving tissue characterization and reproducibility, but high-resolution 3D prostate MRF is still relatively new and undergoing validation.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIANG, YUN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: JIANG, YUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Detection, Cancers