High-resolution 3D maps of DNA folding in different cells and species
Official title: High-resolution reconstruction of 3D spatial genome architectures for multi-level biological contexts
Funded at Michigan State University · NIH-11536500 · Data updated 2026-11-12
A researcher is developing new computer models to reconstruct detailed 3D maps of how DNA folds inside cells across different cell types, genotypes, and species.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $294,266 |
| NIH project number | 1R01GM169394-01 |
| Project ID | NIH-11536500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are researchers and clinicians interested in genome structure and its relation to disease who can apply these high-resolution models to their own data.
✕Less likely to help
Patients are not directly enrolled in this computational modeling project.
What this research studies
This project aims to create high-resolution 3D representations of genome architecture to better understand how DNA folding affects biology. Using advanced math and computer modeling, it will fill gaps where data is missing or hard to measure, so scientists can compare genome structure across contexts. By focusing on diverse biological backgrounds, the work intends to reveal how spatial organization relates to function in health and disease. The research is led by a team at Michigan State University and will generate methods that other scientists can apply to study chromatin structure.
Why it matters
Potential benefit: If successful, this work could enable researchers to interpret how genome organization influences gene activity across different cells and species, potentially guiding precision approaches in biology and medicine.
How similar studies have gone: Previous efforts show that high-resolution 3D genome modeling is feasible in some contexts, but this project aims to extend it to more diverse biological contexts.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Wang, Jianrong — Michigan State University
- Study coordinator: Wang, Jianrong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.