High-precision laser spectroscopy integrated into liquid chromatography for faster bioformulation analysis
Official title: Integration of High-Precision Tunable Laser Spectroscopy (HPTLS) into Liquid Chromatography for Quantitative Bioformulation Analysis
Funded at Nirrin Technologies INC · NIH-11409439 · Data updated 2026-11-12
A new SBIR project aims to combine a laser-based detection technology with standard liquid chromatography to quickly identify and measure all components of biopharmaceutical formulations.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nirrin Technologies INC NIH-funded |
| Lab location | 1 site (Billerica, United States) |
| Project start | September 1, 2026 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,156,172 |
| NIH project number | 1R44GM165281-01 |
| Project ID | NIH-11409439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; applicable to biopharmaceutical manufacturers and their products used by patients.
✕Less likely to help
Direct patient benefit is not part of this grant; it targets process improvement in drug manufacturing.
What this research studies
This project brings a cutting-edge spectroscopic detector into routine LC workflows to quantify proteins, nucleic acids, excipients, and degradants in one step. It seeks to reduce the need for multiple separate tests, saving time and material. The approach could lower costs and speed up quality control in biopharma manufacturing, with a focus on real-world formulation analysis. The funding supports development through Phase II, moving from a lab concept toward a practical, deployable tool.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more reliable quality control of biopharmaceuticals, potentially improving product safety and availability.
How similar studies have gone: SBIR efforts targeting integrated detection methods have shown promise in accelerating analytical workflows, though full integration into LC is an emerging area.
Where this research is happening
-
Nirrin Technologies INC
Billerica, United States Active
Researchers
- Principal investigator: Hassell, Bryan — Nirrin Technologies INC
- Study coordinator: Hassell, Bryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.