High-detail ultrasound to image heart blood flow in mice
Murine cardiac vector-flow imaging with high-frequency 2D row-column CMUT arrays
This project develops a new high-frequency ultrasound tool to capture very fast, tiny blood-flow patterns and heart motion in mice used to study heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11160673 on NIH RePORTER |
What this research studies
Researchers are building a high-frequency, 2D ultrasound array and a fast imaging method that can capture full-frame pictures of blood flow and heart motion in mice at sub-millisecond speed. They will test the system on mouse models of heart disease to map complex intracardiac flow and early mechanical changes before obvious damage appears. The approach uses a novel CMUT row-column array and plane-wave vector-flow imaging to get higher-resolution flow and motion data than standard small-animal ultrasound. The goal is to give scientists a better preclinical tool to link blood flow changes with heart dysfunction and speed translational work.
Who could benefit from this research
Good fit: This project does not enroll people; it focuses on mouse models in a research lab rather than on patient participants.
Not a fit: Patients should not expect direct clinical benefits or access to new imaging from this work right now because it is preclinical and performed in animals.
Why it matters
Potential benefit: If successful, this could help researchers detect early heart dysfunction in preclinical studies and accelerate development of improved treatments for cardiovascular disease.
How similar studies have performed: Vector-flow ultrasound has shown promise in human cardiac imaging, but adapting high-frequency vector-flow methods for mice is novel and largely untested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Ketterling, Jeffrey — Weill Medical Coll of Cornell Univ
- Study coordinator: Ketterling, Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.