Hemocompatible ECMO Membranes to Reduce Clotting and Bleeding
Official title: Optimization Of Hemocompatible ECMO Membranes: A Synergistic Strategy Combining Biomimetic Surface Modification And Computational Fluid Dynamics
Funded at Colorado State University · NIH-11460988 · Data updated 2026-11-12
A project will test a new surface-treated ECMO membrane design to reduce blood clots and bleeding risks in patients needing ECMO support.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $231,000 |
| NIH project number | 1R21EB040308-01 |
| Project ID | NIH-11460988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acquired von Willebrand syndrome/disease or ECMO-related clotting risks could benefit from safer membrane designs.
✕Less likely to help
This study focuses on materials and design; direct patient benefit may be limited to future device improvements rather than immediate treatment changes.
What this research studies
This project aims to improve ECMO membranes by applying biomimetic surface modifications and using computational fluid dynamics to understand and reduce clotting triggers. It focuses on how blood interacts with the membrane surface and flow, aiming to keep blood components intact while maintaining gas exchange. The work builds on prior static tests and seeks to validate durable, blood-friendly surfaces in more realistic flow conditions.
Why it matters
Potential benefit: If successful, the improved membranes could lower clotting and bleeding complications for ECMO patients, potentially reducing transfusions and improving outcomes.
How similar studies have gone: Previous surface-mimicking approaches showed promising hemocompatibility in static tests; this study advances toward flow-based validation.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Kipper, Matthew — Colorado State University
- Study coordinator: Kipper, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.