Helping the Heart Repair Itself for Heart Failure
Induction of Cardiomyocyte Proliferation via Transient Expression of Cell Cycle Factors as a Promising Therapy for Heart Failure
This work explores ways to encourage adult heart muscle cells to regrow and repair damage caused by heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10981036 on NIH RePORTER |
What this research studies
When the heart is damaged, it struggles to fix itself because its muscle cells stop dividing. Our goal is to find ways to restart this cell division, which could help the heart heal. We are developing a new system that delivers specific factors directly to heart muscle cells, encouraging them to multiply. This approach has shown promise in animal models, and we are working to make it ready for human use.
Who could benefit from this research
Good fit: This foundational work is for patients with heart failure who may benefit from future therapies that regenerate heart muscle.
Not a fit: Patients who do not have heart failure or conditions related to heart muscle damage may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could lead to new treatments that help patients with heart failure by repairing damaged heart muscle and improving heart function.
How similar studies have performed: Previous work has shown that similar methods can induce heart muscle cell proliferation and repair in preclinical animal models.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Mohamed, Tamer M a — Baylor College of Medicine
- Study coordinator: Mohamed, Tamer M a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.