Helping people who smoke and vape to quit

Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape

NIH-funded research University of Wisconsin-Madison · NIH-11075908

This study is looking for ways to help people who smoke regular cigarettes and use e-cigarettes quit for good, and it’s inviting 500 motivated participants to try out different treatment options, like medications and counseling, to see which methods work best for them.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Wisconsin-Madison NIH-funded
Lab location1 site (Madison, United States)
Project IDNIH-11075908 on NIH RePORTER

What this research studies

This research investigates effective ways to help individuals who use both combustible cigarettes and e-cigarettes quit smoking. It will enroll 500 participants who are motivated to quit and will use a randomized trial to compare different treatment approaches, including medications and counseling strategies. The study aims to identify which combination of pharmacotherapy and counseling is most effective for dual users. Participants will be guided through either a dual-focused approach that addresses both smoking and vaping or a smoking-focused approach that allows for strategic use of e-cigarettes.

Who could benefit from this research

Good fit: Ideal candidates are adults who currently use both combustible cigarettes and e-cigarettes and are motivated to quit smoking.

Not a fit: Patients who exclusively use e-cigarettes or do not smoke combustible cigarettes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide tailored interventions that significantly improve cessation rates for individuals who smoke and vape.

How similar studies have performed: While there is limited research specifically targeting dual users, similar cessation approaches have shown promise in helping smokers quit.

Where this research is happening

Madison, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cancers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.