Helping people who smoke and vape to quit
Official title: Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape
Funded at University of Wisconsin-Madison · NIH-11075908 · Data updated 2026-11-12
This study is looking for ways to help people who smoke regular cigarettes and use e-cigarettes quit for good, and it’s inviting 500 motivated participants to try out different treatment options, like medications and counseling, to see which methods work best for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | May 1, 2024 |
| Project end | May 1, 2029 |
| Funding year | 2025 |
| Award (this year) | $856,188 |
| NIH project number | 5R01CA290895-02 |
| Project ID | NIH-11075908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults who currently use both combustible cigarettes and e-cigarettes and are motivated to quit smoking.
✕Less likely to help
Patients who exclusively use e-cigarettes or do not smoke combustible cigarettes may not benefit from this research.
What this research studies
This research investigates effective ways to help individuals who use both combustible cigarettes and e-cigarettes quit smoking. It will enroll 500 participants who are motivated to quit and will use a randomized trial to compare different treatment approaches, including medications and counseling strategies. The study aims to identify which combination of pharmacotherapy and counseling is most effective for dual users. Participants will be guided through either a dual-focused approach that addresses both smoking and vaping or a smoking-focused approach that allows for strategic use of e-cigarettes.
Why it matters
Potential benefit: If successful, this research could provide tailored interventions that significantly improve cessation rates for individuals who smoke and vape.
How similar studies have gone: While there is limited research specifically targeting dual users, similar cessation approaches have shown promise in helping smokers quit.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Piper, Megan E — University of Wisconsin-Madison
- Study coordinator: Piper, Megan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.