Helping people in opioid use disorder treatment who smoke switch to a research e-cigarette

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11122355

This project explores if using a specific research e-cigarette can help people receiving medication for opioid use disorder reduce their cigarette smoking.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorMASSACHUSETTS GENERAL HOSPITAL (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-11122355 on ClinicalTrials.gov

What this research studies

Many people receiving medication for opioid use disorder also smoke cigarettes, and it's often harder for them to quit. This project looks at whether switching from regular cigarettes to a special research e-cigarette could be a helpful step for those who aren't ready to fully stop smoking. We want to see if this switch is practical, acceptable to patients, and if it can start to reduce their tobacco use and exposure to harmful chemicals. This information could guide future care and policy decisions for this group.

Who could benefit from this research

Good fit: Ideal candidates are individuals aged 21 or older who are receiving medication treatment for opioid use disorder and currently smoke cigarettes but are not ready to quit.

Not a fit: Patients who do not smoke cigarettes or are not receiving medication for opioid use disorder would not directly benefit from this specific approach.

Why it matters

Potential benefit: If successful, this approach could offer a new way for individuals in opioid use disorder treatment to reduce the harm from cigarette smoking, even if they are not yet ready to quit entirely.

How similar studies have performed: While e-cigarettes are generally considered a harm reduction strategy, little work has specifically tested this approach in individuals receiving medication treatment for opioid use disorder who smoke.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.