Helping obese patients with Peripheral Artery Disease maintain their mobility through weight loss
Official title: 2/2 PROmote weight loss in obese PAD patients to preVEnt mobility loss: The PROVE Trial--DCC
Funded at Wake Forest University Health Sciences · NIH-10889916 · Data updated 2026-11-12
This research helps obese patients with Peripheral Artery Disease (PAD) lose weight to keep them moving and active.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | June 10, 2019 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $200,993 |
| NIH project number | 5U24HL141732-06 |
| Project ID | NIH-10889916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are obese individuals diagnosed with Peripheral Artery Disease who are interested in a weight loss program to improve their mobility.
✕Less likely to help
Patients who are not obese or do not have Peripheral Artery Disease would not be the focus of this specific weight loss approach.
What this research studies
For patients living with Peripheral Artery Disease (PAD) who are also obese, losing weight might help prevent further loss of mobility. This research looks at whether a weight loss program can effectively help these patients stay active. We are carefully collecting and managing all the information from participants to ensure the study is well-organized and the results are reliable. The goal is to understand if weight loss can be a key strategy to improve daily life for people with PAD.
Why it matters
Potential benefit: If successful, this research could show that weight loss is an effective way to preserve mobility for obese individuals living with Peripheral Artery Disease.
How similar studies have gone: While the benefits of weight loss are generally known, this specific approach to prevent mobility loss in obese PAD patients is being rigorously tested in this trial.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Ambrosius, Walter T — Wake Forest University Health Sciences
- Study coordinator: Ambrosius, Walter T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.