Helping new blood vessels heal and become normal after injury
Modulating the resolution of angiogenesis and normalization of the vasculature for therapeutic benefit
This project develops ways to help new blood vessels mature and stop leaking so people with blocked or damaged arteries can get better blood flow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11258509 on NIH RePORTER |
What this research studies
If you have poor blood flow from blocked or damaged arteries, this research looks for ways to make new blood vessels mature and become less leaky so tissues can heal. Scientists will work in the lab using cells and animal models and will employ gene-delivery tools such as adeno-associated viruses to probe the signals that tell vessels to stop growing and stabilize. They will measure vessel structure, leakiness, and blood flow in these models and test molecular approaches that promote healthy vessel normalization. The aim is to turn those findings into therapies that could be tried in people with peripheral artery disease and other ischemic cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates would be people with peripheral artery disease or other ischemic conditions where inadequate or disorganized blood vessel growth limits blood flow and tissue repair.
Not a fit: People without vascular or ischemic problems, or whose condition is caused by non-vascular issues, are unlikely to benefit from these specific therapies.
Why it matters
Potential benefit: If successful, this work could lead to treatments that create more stable, less leaky blood vessels and improve blood flow and healing in people with ischemic vascular disease.
How similar studies have performed: Prior angiogenesis efforts (for example VEGF or cell therapies) have had mixed clinical results, and focusing on vessel 'resolution' and normalization is a newer approach with promising preclinical rationale but limited clinical proof so far.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Antalis, Toni M — University of Maryland Baltimore
- Study coordinator: Antalis, Toni M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.