Helping Middle-Aged Adults Stay Active to Lower Alzheimer's Risk

Targeting Cognitive Control to Improve Physical Activity Adherence in Midlife for Alzheimer's Risk Reduction

NIH-funded research University of Iowa · NIH-11110498

This project explores how improving mental focus can help middle-aged adults stay physically active, which may lower their risk for Alzheimer's disease.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Iowa NIH-funded
Lab location1 site (Iowa City, United States)
Project IDNIH-11110498 on NIH RePORTER

What this research studies

Even though physical activity is known to help keep our brains healthy as we age, many middle-aged adults find it hard to start and stick with exercise routines. This research suggests that our ability to control our thoughts and actions, called cognitive control, is key to successfully adopting and maintaining physical activity. We will test if specific brain training exercises can improve this cognitive control, making it easier for people to follow through on their exercise plans. The project also looks at whether using emotionally meaningful cues during this training can further boost how well people stick to moderate-to-vigorous physical activity. The goal is to develop new ways to help people maintain healthy habits for better brain health.

Who could benefit from this research

Good fit: Ideal candidates are inactive middle-aged adults interested in improving their physical activity habits and reducing their risk for cognitive decline.

Not a fit: Patients already consistently active or those with advanced cognitive impairment may not directly benefit from this specific intervention.

Why it matters

Potential benefit: If successful, this work could lead to new strategies to help middle-aged adults consistently engage in physical activity, potentially reducing their risk of Alzheimer's disease and age-related cognitive decline.

How similar studies have performed: While the importance of cognitive control in physical activity is recognized, this grant aims to causally test if cognitive training can directly improve physical activity adherence.

Where this research is happening

Iowa City, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.