Helping men stay on PrEP by combining group support with coordinated services

A Multi-Level Integrated Strategy to Optimize PrEP Adherence and Accelerate Implementation at Scale

NIH-funded research Yale University · NIH-11392851

This project combines group-based support and a coordinated online care system to help men stay on HIV prevention medication (PrEP).

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-11392851 on NIH RePORTER

What this research studies

You would be offered group sessions (Many Men Many Voices) that build motivation and healthcare-seeking skills, while staff trained in client-centered care help connect you to services. An online C4 platform links you to a network of providers and supports continuity between visits. The project brings these two approaches together at two agencies in communities with high HIV rates and follows participants to see if people stay on PrEP more consistently. The team aims to reduce interpersonal and structural barriers that make it hard to keep taking PrEP.

Who could benefit from this research

Good fit: Men at elevated risk for HIV in high-incidence U.S. communities who are eligible for or already taking PrEP and face social or structural barriers to staying on medication.

Not a fit: People not at risk for HIV, those who cannot attend local group sessions or access the participating agencies or online platform, or those using alternative prevention approaches may not benefit.

Why it matters

Potential benefit: If successful, this could help people maintain PrEP use more reliably and lower their chance of getting HIV.

How similar studies have performed: Related group-based interventions and care-coordination models have shown promise in improving healthcare engagement, but combining 3MV with the C4 platform is a novel, larger-scale approach.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.