Helping doctors recommend the HPV vaccine more effectively

PCOM2 - The Physician Communication Intervention, Version 2.0

NIH-funded research University of Colorado Denver · NIH-11241110

It teaches doctors a two-step way to recommend the HPV vaccine to parents of 11–12 year-olds to help more adolescents start the vaccine series.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Colorado Denver NIH-funded
Lab location1 site (Aurora, UNITED STATES)
Project IDNIH-11241110 on NIH RePORTER

What this research studies

This project trains pediatric and primary care providers to use a two-step recommendation: begin with a confident, presumptive statement like “Let’s get the HPV vaccine today,” and then use brief motivational interviewing to address parental hesitancy if needed. The team delivers training and coaching in real clinic settings so providers can practice during normal visits. They track how many 11–12 year-olds begin the HPV vaccine series and whether the approach can be sustained in busy clinics. This version builds on a prior large trial that increased vaccination starts by about 8 percentage points.

Who could benefit from this research

Good fit: Ideal candidates are parents and 11–12 year-old adolescents receiving care at participating pediatric or family medicine clinics.

Not a fit: People who are already up-to-date on HPV vaccination, older than the adolescent vaccination window, or who do not attend participating clinics are unlikely to get direct benefit.

Why it matters

Potential benefit: If successful, more adolescents would start the HPV vaccine series, reducing future HPV-related cancers.

How similar studies have performed: An earlier large cluster-randomized trial of the original PCOM intervention raised HPV vaccine initiation by about 8 percentage points, so this approach has prior evidence of benefit.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Anogenital cancerCervical CancerCervix Cancer
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.