Helping children with short bowel syndrome absorb nutrients better with RELiZORB
A 90 day, Phase 3, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children with Short Bowel Syndrome who are Dependent on Parenteral Nutrition
This project looks at how a special enzyme called RELiZORB can help children with short bowel syndrome, who receive nutrition through a vein, better absorb fats and other nutrients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10891341 on NIH RePORTER |
What this research studies
Children with short bowel syndrome often struggle to absorb enough nutrients because a large part of their small intestine is missing or doesn't work well. Many of these children rely on feeding through a vein, called parenteral nutrition (PN), which can lead to serious health problems over time. This project aims to see if adding RELiZORB, an enzyme that helps break down fats, can improve how well these children absorb nutrients from their regular food. By improving fat absorption, the hope is to reduce the complications associated with long-term PN and help children get more nutrition from their gut.
Who could benefit from this research
Good fit: Ideal candidates are children with short bowel syndrome who depend on nutrition delivered through a vein.
Not a fit: Patients who do not have short bowel syndrome or are not dependent on parenteral nutrition would not benefit from this specific approach.
Why it matters
Potential benefit: If successful, this could help children with short bowel syndrome absorb more essential fats and nutrients, potentially reducing their reliance on intravenous feeding and improving their overall health.
How similar studies have performed: As a Phase 3 effort, earlier phases of this work have likely shown promising results regarding safety and potential benefits.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Puder, Mark — Boston Children's Hospital
- Study coordinator: Puder, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.