Helping cells stay healthier as we age by fixing ER–mitochondria calcium signaling
Targeting ER-mitochondrial calcium signaling to promote healthier aging
This work will see if restoring calcium communication between two cell parts (the ER and mitochondria) keeps cells healthier with age and could lower risk for Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11308737 on NIH RePORTER |
What this research studies
The team uses tiny roundworms (C. elegans) and powerful genetics and microscopy to watch how calcium moves between the endoplasmic reticulum (ER) and mitochondria. They focus on an ER calcium channel called InsP3R and study how its activity changes mitochondrial gene expression, dynamics, and the worms' lifespan. By mapping how ER–mitochondrial contacts remodel during aging, the researchers aim to find cellular ways to protect mitochondrial function that could guide future therapies for Alzheimer's and other age-related conditions.
Who could benefit from this research
Good fit: People concerned about age-related cognitive decline or at higher risk for Alzheimer's who want to support research into cellular aging would be the most directly aligned with this work.
Not a fit: Patients with advanced Alzheimer's or conditions not linked to mitochondrial dysfunction are unlikely to see direct benefits from this basic laboratory research in the near term.
Why it matters
Potential benefit: If successful, this research could point to new targets for preserving mitochondrial health and slowing cellular aging, which might eventually lead to treatments that reduce Alzheimer's risk or progression.
How similar studies have performed: Prior studies in cells and animal models have linked ER–mitochondrial calcium signaling to mitochondrial function and lifespan, but translating these findings to human Alzheimer's treatment is still early and unproven.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Burkewitz, Kristopher — Vanderbilt University
- Study coordinator: Burkewitz, Kristopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.