Help to quit both smoking and vaping
Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11325048
Compares two medicines (varenicline vs nicotine patch) and different counseling styles to find what helps adults who both smoke cigarettes and use e-cigarettes quit smoking and, if asked, stop vaping.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11325048 on ClinicalTrials.gov |
What this research studies
If you both smoke combustible cigarettes and use e-cigarettes and want to quit, you could join a randomized trial of about 500 people. Participants are randomly assigned to varenicline or a nicotine patch and to counseling that either encourages quitting both products or focuses on quitting smoking while using e-cigarettes strategically, in a factorial design. The study team will keep in touch with active phone follow-up and use biochemical tests (like carbon monoxide or other assays) to check smoking abstinence. The goal is to compare combinations of medicine and counseling to identify the most helpful package for dual users.
Who could benefit from this research
Good fit: Adults who currently both smoke combustible cigarettes and use e-cigarettes, are motivated to quit smoking, and are willing to stop vaping if asked.
Not a fit: People who only vape or only smoke, those not willing to try quitting, or those with medical reasons they cannot use varenicline or nicotine patches may not benefit from this trial.
Why it matters
Potential benefit: Could identify the best medicine and counseling combination to help people who both smoke and vape quit more often.
How similar studies have performed: Medications like varenicline and nicotine patches work for cigarette-only smokers, but prior research on people who both smoke and vape is limited and mixed, so this is one of the first large randomized tests focused on dual use.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIPER, MEGAN E — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: PIPER, MEGAN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers