Heart Energy Production in Cardiac Health and Disease
Mitochondrial ATP Synthase in Cardiac Biology and Disease
This project explores how the heart's main energy-making machine, called ATP synthase, works in heart health and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11084509 on NIH RePORTER |
What this research studies
Our hearts rely on a special energy-making process to keep beating strongly. This project looks closely at a key part of that process, called ATP synthase, which creates most of the energy in heart cells. We are learning how problems with this energy system can lead to serious conditions like heart failure. Understanding these basic mechanisms could help us find new ways to support heart health in the future.
Who could benefit from this research
Good fit: Patients with heart failure or those at risk for it could potentially benefit from future treatments developed based on the discoveries from this foundational work.
Not a fit: Patients not affected by heart conditions related to energy production in heart cells may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could uncover new targets for medicines to prevent or treat heart failure by improving how heart cells produce energy.
How similar studies have performed: This project is novel as it uses new mouse models to study the ATP synthase's function in the heart for the first time in living organisms.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Kitsis, Richard N — Albert Einstein College of Medicine
- Study coordinator: Kitsis, Richard N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.