Heart and lung health after tuberculosis (HALO Post-TB)
Heart and Lung Outcomes Post-TB (HALO Post-TB)
This project looks at heart and lung health in people who have had tuberculosis and how HIV might change those outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11378095 on NIH RePORTER |
What this research studies
You would be asked to have detailed lung tests (including full pulmonary function testing and carbon monoxide diffusion), heart imaging and measurements (such as echocardiography), exercise testing to measure fitness, and blood samples taken. The team will compare people who had TB with and without HIV and follow them over time to see how common and how severe heart and lung problems are after TB. Tests and follow-up will occur at clinics in a high TB and HIV burden country, and researchers will look for biological markers that help explain the problems. The study aims to map who develops lasting problems and why so care can be improved.
Who could benefit from this research
Good fit: Adults who have completed treatment for tuberculosis, especially those living in high TB/HIV burden settings and people with or without HIV, are the likely candidates.
Not a fit: People without a history of tuberculosis, those currently being treated for active TB, or those unable to attend study visits in the study locations are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, this work could help doctors detect and treat long-term heart and lung problems in people who survived TB.
How similar studies have performed: Previous studies using lung function tests, echocardiography, and exercise testing have linked HIV to worse cardiopulmonary markers, but combining these tests specifically in people after TB is largely new.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.