Health Literacy and Brain Health in Middle-Aged Adults

Health Literacy and Cognitive Function among Middle-Aged Adults: The MidCog Study

NIH-funded research Northwestern University · NIH-11105797

This project looks at how health knowledge and self-care skills in middle-aged adults might affect their brain health later in life.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorthwestern University NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11105797 on NIH RePORTER

What this research studies

This project aims to understand how factors in middle age, like how well you understand health information and manage your own care, might influence your memory and thinking abilities as you get older. We are recruiting middle-aged adults (ages 40-64) to join a group that will be followed over time. By looking at this age group, which is often overlooked in brain health research, we hope to find ways to prevent cognitive problems like Alzheimer's disease before they start. Many important health habits and conditions begin in middle age, and improving health literacy could be a key to protecting brain health.

Who could benefit from this research

Good fit: Ideal candidates are middle-aged adults, specifically those between 40 and 64 years old, interested in understanding how their health choices impact future brain health.

Not a fit: Patients who are already experiencing significant cognitive impairment or are outside the middle-aged adult range may not directly benefit from participating in this specific observational cohort.

Why it matters

Potential benefit: If successful, this work could help identify new ways to prevent or delay cognitive decline and Alzheimer's disease by focusing on health habits and understanding in middle age.

How similar studies have performed: While some studies have looked at cognitive changes in older adults, this project is novel in its focus on a diverse group of middle-aged adults and the specific role of health literacy in preventing later-life cognitive impairment.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer's disease and related dementia
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.