Harnessing the immune system to fight pediatric cancers
Pediatric Ohio-New York Cancer (Peds-ONC) Immunotherapy Center
This study is working on new ways to use your body's own immune system to help treat childhood cancers, focusing on special immune cells that can fight cancer better, and it's for kids who are facing these tough battles.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10217461 on NIH RePORTER |
What this research studies
This research focuses on developing innovative immunotherapy approaches to treat pediatric cancers by utilizing the body's innate immune system. The Pediatric Ohio-New York Cancer Immunotherapy Center aims to identify and overcome challenges in using natural killer (NK) cells and CAR-NK cells as effective cancer treatments. The research will also explore ways to enhance immunotherapies by targeting suppressive myeloid cells and breaking tolerance to cancer-associated proteins. The project involves collaboration between major medical centers in Ohio and New York, leveraging advanced genomic and immune monitoring technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with various types of cancer who have not responded well to conventional therapies.
Not a fit: Patients with cancers that are not amenable to immunotherapy or those who are not eligible for clinical trials may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pediatric cancers, improving survival rates and quality of life for young patients.
How similar studies have performed: Previous research has shown promising results in utilizing immunotherapy approaches for pediatric cancers, indicating potential for success in this novel application.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Cripe, Timothy P — Research Inst Nationwide Children's Hosp
- Study coordinator: Cripe, Timothy P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.