Harmonizing cell types from single cell data across different human organs
Official title: Cell type harmonization of single cell data in HuBMAP and GTEx
Funded at J. Craig Venter Institute, INC. · NIH-10777089 · Data updated 2026-11-12
This study is working to create a detailed map of healthy human cells from different organs to help us understand how they work, which could lead to better ways to diagnose and treat diseases for patients like you.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. Craig Venter Institute, INC. NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 20, 2023 |
| Project end | September 19, 2025 |
| Funding year | 2023 |
| Award (this year) | $390,000 |
| NIH project number | 1R03OD036499-01 |
| Project ID | NIH-10777089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect specific organs or those interested in the genetic basis of organ health.
✕Less likely to help
Patients with rare or undiagnosed conditions that do not involve the organs studied may not receive direct benefits from this research.
What this research studies
This research aims to create a comprehensive reference of healthy human cells by harmonizing single cell genomic data from various organs. It utilizes advanced computational algorithms to analyze and match cell types from large datasets generated by international consortia, specifically the Human BioMolecular Atlas Program (HuBMAP) and Genotype-Tissue Expression (GTEx). By applying rigorous data quality control and machine learning techniques, the project seeks to improve our understanding of organ-specific and cross-organ cell types, which could enhance biomarker identification for various diseases. Patients may benefit from insights gained through this research, as it could lead to better diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could provide a more accurate understanding of cell types in human organs, leading to improved disease diagnosis and treatment.
How similar studies have gone: Other research has successfully utilized similar computational approaches to analyze single cell data, indicating potential for impactful findings in this area.
Where this research is happening
-
J. Craig Venter Institute, INC.
La Jolla, United States Active
Researchers
- Principal investigator: Dupont, Christopher L. — J. Craig Venter Institute, INC.
- Study coordinator: Dupont, Christopher L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.