Gyrate Atrophy: Understanding Vision Loss and Metabolism
Official title: Gyrate Atrophy Ocular and Systemic Study (GYROS)
Funded at Jaeb Center for Health Research, INC. · NIH-11162268 · Data updated 2026-11-12
A study of people with Gyrate Atrophy to map how the disease progresses and how blood ornithine levels relate to eye health, with a goal of paving the way for future therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jaeb Center for Health Research, INC. NIH-funded |
| Lab location | 1 site (Tampa, UNITED STATES) |
| Project start | September 15, 2022 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $400,000 |
| NIH project number | 5R01FD007628-03 |
| Project ID | NIH-11162268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with confirmed gyrate atrophy due to OAT gene variants, on standard dietary management, who can participate in long-term follow-up and metabolic testing.
✕Less likely to help
Those with unrelated eye conditions or unable to participate in long-term follow-up or blood testing may not directly benefit.
What this research studies
This project follows people with gyrate atrophy over several years to document how their vision and eye structure change and how metabolic measurements reflect those changes. It will collect fasting amino acid levels, eye imaging results, and patient-reported outcomes to build a clear picture of disease progression under current dietary management. Researchers will also look for patterns that predict quicker decline, considering genetic, metabolic, and environmental factors. The findings should help design future interventional trials, including potential gene-based therapies, while reducing burdens from current treatments.
Why it matters
Potential benefit: If successful, the study could accelerate development of a therapy that preserves vision and lessens the need for a strict diet.
How similar studies have gone: Previous natural-history studies in rare retinal diseases have informed trial design, but this study focuses on OAT-related gyrate atrophy and its metabolic-structural links.
Where this research is happening
-
Jaeb Center for Health Research, INC.
Tampa, United States Active
Researchers
- Principal investigator: Ayala, Allison Renee — Jaeb Center for Health Research, INC.
- Study coordinator: Ayala, Allison Renee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.