Gut microbes influence the development and function of intestinal cells
Key gut microbes shape intestinal epithelial lineage development, differentiation and metabolic function
This study is looking at how a specific gut bacteria called Prevotella copri affects the health of the intestines in both healthy and undernourished children, with the goal of finding ways to improve gut health through diet or other treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10978208 on NIH RePORTER |
What this research studies
This research investigates how gut microbes, particularly a species called Prevotella copri, affect the development and specialization of intestinal cells. By studying both healthy and undernourished children, the researchers aim to understand how these microbes and their metabolic products can influence growth and metabolic functions in the intestines. Using advanced techniques like single-nucleus RNA sequencing and gnotobiotic mouse models, the study explores the relationship between gut microbiota and intestinal health, particularly in young children. The findings could provide insights into how gut health can be improved through dietary or microbial interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years, especially those from undernourished backgrounds or with gut health issues.
Not a fit: Patients who are adults or those without any gut health concerns may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving gut health and growth in children, particularly those who are malnourished.
How similar studies have performed: Other research has shown promising results in understanding the role of gut microbiota in health, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wang, Yi — Washington University
- Study coordinator: Wang, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.