Gut microbes influence immune pathways in intestinal stem cells.
Gut microbes modulate immune pathways in intestinal stem cells to influence their lineage
This study is looking at how the tiny microbes in our gut can influence the behavior of special cells in our intestines that help keep us healthy, using fruit flies to learn more about how these microbes might help or hinder our gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10842450 on NIH RePORTER |
What this research studies
This research investigates how gut microbes affect the behavior of intestinal stem cells (ISCs) and their differentiation into various cell types. By using the fruit fly Drosophila melanogaster as a model organism, the researchers aim to understand the mechanisms through which different types of microbes can either promote or inhibit ISC proliferation and differentiation. The study will explore the role of immune signaling pathways in these processes, potentially revealing how microbial interactions can impact intestinal health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in the role of gut health in overall well-being.
Not a fit: Patients with non-gastrointestinal conditions or those not affected by gut microbiota may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating intestinal diseases by targeting gut microbiota.
How similar studies have performed: Other research has shown promising results in understanding the role of gut microbes in health and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Buchon, Nicolas — Cornell University
- Study coordinator: Buchon, Nicolas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.