Gut microbes and drug response in inflammatory disease
Official title: From here to eternity: gut microbial response to drug therapy and inflammation
Funded at Northern California Institute/res/edu · NIH-11380902 · Data updated 2026-11-12
A research program to understand which gut microbes and their genes react to inflammation and drug therapy, and how these changes affect health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $383,250 |
| NIH project number | 5R35GM151349-04 |
| Project ID | NIH-11380902 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with inflammatory diseases who are undergoing drug therapy and have gut microbiome involvement.
✕Less likely to help
Patients not experiencing gut microbiome-related effects or those not undergoing relevant drug therapy may see no direct benefit.
What this research studies
This grant funds a long-term project to map which gut microbial genes respond when inflammation occurs or when patients take certain medications. Researchers will combine microbiology, genetics, and clinical data to link microbial activity to how well drugs work and how disease symptoms change. The study aims to build knowledge that could guide microbiome-targeted therapies in inflammatory conditions. It is led by Renuka Rajendra Nayak and will be conducted at the Northern California Institute/Res Edu in San Francisco over five years.
Why it matters
Potential benefit: If successful, patients could benefit from more personalized microbiome-based treatments that improve drug responses and reduce inflammation.
How similar studies have gone: Previous work shows microbiome links to disease; this grant proposes a deeper, gene-level understanding that is still being explored.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Nayak, Renuka Rajendra — Northern California Institute/res/edu
- Study coordinator: Nayak, Renuka Rajendra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.