Gut microbes and blood chemical lab supporting HIV work
Integrated Metagenomic and Metabolomic Core
['FUNDING_P01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11169831
This project measures gut microbes and blood chemicals to learn how probiotics and related factors link to health for people living with HIV.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11169831 on ClinicalTrials.gov |
What this research studies
If you join a linked study, researchers will collect stool and blood samples and run DNA sequencing and targeted chemical tests to map your gut microbes and circulating metabolites. The core uses 16S rRNA and whole genome shotgun sequencing plus targeted metabolomics on plasma/serum, with strict collection, shipping, and tracking procedures. Advanced computer analyses will combine microbial and metabolite data with clinical outcomes from a probiotics randomized trial and a clinical cohort to look for meaningful patterns. The core supports standardized, high-quality lab work so the linked projects can compare results across participants and time points.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV who are enrolled in the linked probiotic clinical trial or clinical cohort and who can provide stool and blood samples.
Not a fit: People not enrolled in the program's linked studies or those unwilling to provide the required samples are unlikely to receive direct benefit from this core.
Why it matters
Potential benefit: Findings could point to microbiome or metabolite markers and help guide better probiotic or metabolic approaches to improve health in people with HIV.
How similar studies have performed: Prior microbiome and metabolomics studies in people with HIV have shown promising links but probiotic benefits have been mixed, so this integrated approach builds on existing work while adding new, more detailed data.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARVE, SHIRISH S — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: BARVE, SHIRISH S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus