Gut bacteria that trigger inflammation in Crohn’s disease
The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s disease
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11322140
This project looks at specific gut bacteria that cause a key inflammatory signal (IL‑1β) in people with Crohn’s disease to learn how they make gut inflammation worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11322140 on ClinicalTrials.gov |
What this research studies
Researchers are studying certain gut bacteria, called pathobionts, that are more common in people with Crohn’s and that make immune cells release IL‑1β. They will use patient-derived samples and laboratory models to see how long-term colonization by these bacteria changes the gut and the bone marrow to promote inflammation. The team will examine how these bacteria stick to the gut lining and whether innate immune cells or epithelial cells retain an inflammatory "memory." Results could point to ways to prevent flare-ups by targeting the bacteria or the IL‑1β signal.
Who could benefit from this research
Good fit: Ideal candidates would be people with Crohn’s disease, especially those with active or recurrent inflammation, who may provide stool or tissue samples for research.
Not a fit: People without Crohn’s disease, or those whose symptoms are driven by non-bacterial causes, are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or prevention strategies that reduce Crohn’s flare-ups by targeting the harmful bacteria or the IL‑1β-driven inflammation.
How similar studies have performed: Previous studies have linked certain gut bacteria to IBD and IL‑1β-driven inflammation, but the long-term colonization effects and bone marrow changes described here are relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAMADA, NOBUHIKO — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KAMADA, NOBUHIKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.