Gut bacteria and early feeding in children with severe pediatric ARDS
Microbiome and Nutrition in Severe PARDS
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11086088
See whether starting tube or formula feeds early changes gut bacteria and reduces lung inflammation in children with severe pediatric ARDS.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11086088 on ClinicalTrials.gov |
What this research studies
If your child is in the PROSpect trial for severe pediatric ARDS, this ancillary project will collect stool samples and clinical information to look at gut bacteria and related chemicals called short-chain fatty acids. The team will use 16S sequencing to map which gut microbes are present and measure butyrate levels that may protect the lungs. They will compare children who get early enteral nutrition (EEN) with those who do not to link feeding, microbes, and lung inflammation. This work is done across multiple hospitals participating in the larger PROSpect trial.
Who could benefit from this research
Good fit: Children (infants through age 11) with severe pediatric ARDS who are enrolled at a PROSpect trial hospital and receiving mechanical ventilation are the ideal candidates.
Not a fit: Children without PARDS, with only mild lung disease, adults, or those not enrolled at participating PROSpect hospitals are unlikely to benefit from this specific study.
Why it matters
Potential benefit: If successful, this could identify an easy, low-cost feeding approach that lowers lung inflammation and may reduce deaths in children with severe PARDS.
How similar studies have performed: Retrospective studies have linked early enteral feeding to lower mortality and animal studies show butyrate can reduce lung injury, but applying these mechanistic tests in children within a randomized trial context is new.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TYPPO, KATRI VANAMO — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: TYPPO, KATRI VANAMO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.