Guiding treatment for leukemia that returns after transplant
A compass for those with relapsed leukemia after transplant
This work aims to find better ways to detect leukemia early after a transplant and help doctors choose the best treatment for each patient.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11093395 on NIH RePORTER |
What this research studies
Many people experience leukemia returning after a stem cell transplant, and while there are new treatments, it's hard to know which one will work best. This project uses advanced single-cell genetic methods to find leukemia cells even when they are at very low levels. We will also look for changes in cells that help leukemia hide from the immune system, which can guide future treatment choices. By combining these detailed genetic insights with traditional cell analysis, we hope to create a more precise way to understand and treat relapsed leukemia.
Who could benefit from this research
Good fit: This research is relevant for patients who have undergone hematopoietic cell transplantation for leukemia and are at risk of relapse.
Not a fit: Patients whose leukemia has not relapsed after transplant or who have other forms of cancer may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection of relapsed leukemia and more personalized treatment plans, potentially improving outcomes for patients.
How similar studies have performed: While single-cell genomic methods are rapidly advancing, this project proposes novel computational and molecular approaches to specifically address leukemia relapse after transplant.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Furlan, Scott Nicholas — Fred Hutchinson Cancer Center
- Study coordinator: Furlan, Scott Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.